Honokiol and magnolol inhibited the growth of acne-causing bacteria Cutibacterium acnes and Cutibacterium granulosum.14 Both phenolic compounds also reduced inflammation by inhibiting the secretion of interleukin-8 and tumor necrosis factor alpha (TNF-alpha) induced by P. acnes. Health Concerns of the Ingredient: Overall Hazard . Found in 4 beauty products. Avoid use if hypersensitivity exists for any of the components in MBE. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. EINECs: 285-376-6. Magnolol is an organic compound that is classified as lignan. With click on ACCEPT, we are using cross-website tools to provide you individual information for marketing purposes via partners, also beyond our website. Magnolia is a plant genus in the family of Magnoliaceae. in the bark of the Houpu magnolia or in M. grandiflora. Developmental & reproductive toxicity . Magnolia is a plant. Magnolia Extract is an emerging cosmeceutical that is showing many skin benefits. Magnolia bark extract is also used in skin care products like NIVEA’s BB Cream Daily Moisturiser to help fade dark spots and pigmentation, and to give the appearance of a soft and even complexion. Last updated on Jul 2, 2020. CAS Number: 85085-47-8 EINECS/ELINCS No: 285-376-6 COSING REF No: 84188 Chem/IUPAC Name: Magnolia Grandiflora Bark Extract is the extract of the bark of the Magnolia grandiflora L., Magnoliaceae Name: magnolia grandiflora l. bark extract: CAS Number: 85085-47-8: ECHA EC Number: 285-376-6: Category: antimicrobial, antioxidants agents . You can also add the extract to your breakfast smoothie. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Honokiol and magnolol also reduced elevated corticosterone concentrations and normalized hypothalamic–pituitary–adrenal hyperactivity and reduced platelet adenylyl cyclase activity by upregulating the cyclic adenosine monophosphate pathway.36, Experimentally induced depression in mice was inhibited by magnolol and its metabolite hydroxydihydromagnolol.37 An ethanol extract of a traditional Chinese medicine containing M. officinalis exhibited antidepressant effects in mice similar to the effects of fluoxetine.38 In a stress-induced model in rats, the combination of honokiol, magnolol, and ginger oil exhibited antidepressant effects. In one small clinical trial, a patient dropped out because of a number of adverse reactions, including heartburn, shaking hands, perilabial numbness, sexual dysfunction, and thyroid dysfunction. However, MBE + xylitol reduced mutans streptococci concentrations (P=0.04) and bleeding upon probing (P=0.04) significantly better than xylitol without MBE.71 (Campus, 2011), Magnolol reduced swelling and inflammation in edema induced by carrageenan, compound 48/80, polymyxin B, and reversed passive Arthus reaction in mice.15 When compared with dexamethasone, magnolol did not increase glycogen levels in the liver. Dosing recommendations include taking a 300 mg capsule of Relora 2 to 3 times per day. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Magnolia bark (Magnolia officinalis) is a traditional Chinese medicine used since 100 A.D. to support the body and nurture wellbeing and to treat a plethora of ailments. A few examples are glycyrrhetinic acid and castor oil , Magnolia grandiflora bark extract , Melaleuca altenifolia or tea tree oil, also containing (oxidized) terpenes , propolis, which often cross-reacts with Myroxylon pereirae , and bisabolol, a component of Compositae plants . People use the bark and flower buds to make medicine. Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent: [ANTIOXIDANTS & REDOX SIGNALING. However, compared to xylitol, MBE + xylitol significantly reduced mutans streptococci concentrations (P=0.04) and bleeding upon probing (P=0.04).71, In 2 double-blind, randomized, placebo-controlled trials in Italy, the acute effect of MBE plus zinc acetate on halitosis was evaluated via 2 doseforms: a sugarless gum and a sugarless tablet. Et Wils.1, 2 Concentration variations of magnolol and honokiol exist in bark sourced from different provinces in China, as recorded in The Pharmacopoeia of the People's Republic of China. Similar antibacterial activity was demonstrated with MBE chewing gum.12 The antibacterial activity of MBE may include nonionic surface agent activity leading to disruption of the cell membrane and lipid protein interface.13. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Read what Magnolia Grandiflora Bark Extract is doing in your skincare and cosmetic formulas and browse products you can find it in. Water or alcohol extracts its virtues. Magnolia bark extract is a fluid alcohol extracted from the bark of a magnolia plant and frequently administered as an herbal medicine. Products Ingredients Decode INCI Login Register. The extract: A magnolia solution was prepared by dissolving the 100 mg of magnolia bark extract per milliliter of dimethyl sulphoxide. Magnolia is used for weight loss, problems with digestion, constipation, inflammation, anxiety, stress, depression, fever, headache, stroke, and asthma.. Magnolia flower bud is used for stuffy nose, runny nose, common cold, sinus pain, hay fever, headache, and facial dark spots. CAS #: 85085-47-8 8508547. Magnolol also attenuated upregulation of renal transforming growth factor beta 1, which plays a key role in the pathogenesis of diabetic nephropathy, and reduced expression of extracellular matrix protein as type IV collagen.40 In mature adipocytes, magnolol improved insulin sensitivity by increasing basal and insulin stimulated glucose uptake through peroxisome proliferator-activated receptors.41 KIOM-4, a plant extract obtained from M. officinalis, protected pancreatic beta cells against streptozotocin-induced oxidative damage.42 KIOM-4 induced a rate-limiting enzyme through the extracellular regulated kinase pathway, which resulted in cytoprotection against diabetic conditions and increased insulin release from the pancreas. Magnolia bark extract is one of the most potent anti-wrinkle ingredients tested so far at NIVEA. Marked by EWG as safe. Magnolia, from these three species, was formerly official. After 12 weeks, the addition of MBE provided a significant improvement in insomnia, irritability, and libido at 4, 8 and 12 weeks.70, A double-blind, randomized, controlled interventional trial (n=120) in Italy investigated the effect of MBE on factors related to dental caries, such as cariogenic bacteria (especially mutans streptococci), fermentable carbohydrates intake, plaque acidity, and saliva flow. MBE was delivered by means of a sugar-free chewing gum containing xylitol, which itself has also been shown to exhibit caries preventative activity. The dosage of the extract should be between 250 to 500 mg per day. You also agree that the data may also be transferred to third countries outside the European Economic Area without an adequate level of data protection (esp. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Celebrated as a herbal remedy for treating the stagnation of qi (energy), for digestive disorders, anxiety and allergic diseases, Magnolia bark extract can also help to prevent the loss of skin elasticity and reduce reddening of the skin. MBE may cause excess sleepiness, vertigo, and dizziness in patients taking muscle relaxants. Normally, the body can handle free radicals, but if antioxidants are unavailable, or if too many free radicals have been produced they can damage our cells. MBE may also have antimicrobial activity against Helicobacter pylori.12, Chewing sugarless gum containing either MBE (0.17%) + xylitol or xylitol without MBE was shown to improve mutans streptococci levels and bleeding on probing significantly better than control. This is only a brief summary of general information about this product. This information should not be used to decide whether or not to take this product. An antioxidant mechanism may be involved with KIOM-79, protecting against oxidative stress-induced apoptosis in diabetic retinopathy.44, Honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5 The mechanism may be associated with blocking receptor-operated cation and voltage-operated calcium channels.5, Magnolol reduced acetaminophen-induced liver damage in rats by inhibiting lipid peroxidation and formation of reactive oxygen species.6 Honokiol reversed the effects of induced alcoholic fatty liver in rats by inhibiting lipid accumulation or fatty acid synthesis.62, A small, controlled, randomized, multicenter study examined the effects of 2 formulations, one containing magnolia bark extract (60 mg) and magnesium (50 mg), in symptomatic menopausal women with sleep or mood alterations. The plant is primarily indigenous to China and found at elevations of 200 to 3,000 meters.3, MBE has been used for over 1,000 years as a folk medicine in Asia.4, 5 In traditional Asian medicine, MBE has been prescribed for treating acute pain, headaches, diarrhea, allergies, asthma, and gynecological disorders. Magnolia bark extract is an ancient herbal remedy from Ancient Chinese medicine. 2011. Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes MBE. It has been used in traditional Chinese medicine called houpu or hou po for hundreds of years, and it is recognized worldwide for its medicinal properties. Magnolia bark extract from Magnolia officinalis contains honokiol and magnolol which have been widely used in the treatment of diseases such as thrombotic.Two constituents exist in magnolia bark, honokiol and magnolol. Inflammation is an important process that our body goes through when it has to fight off infection or repair damaged tissue. These are known to be instrumental in the development of wrinkles, smaller fine lines, sagging skin, blotchiness and skin redness. Documentation on the materials and extracts for several studies is also limited. A total of 123 and 100 adults completed the respective trials. The study summarized above was the only study included that evaluated magnolia bark extract.73. Magnolia bark contains two anti-inflammatory substances, magnolol and honokiol, which reportedly inhibit the activation of NF-KB, a key mediator in both inflammatory and aging processes. Honokiol and magnolol increased serotonin levels in numerous brain regions, while ginger reduced gastric mucosa cholecystokinin and serum gastrin levels.39, Magnolol reduced metabolic parameters common in diabetic nephropathy, such as blood glucose, plasma insulin, sorbitol, and advanced glycation end products in an experimental type 2 diabetes rat model. bark extract skin cellulite magnolia bark magnolia Prior art date 2011-11-02 Legal status (The legal status is an assumption and is not a legal conclusion. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. In this Video, we show you how to make your own herbal magnolia bark tincture! Enrolled participants were adults at high risk of dental caries and were randomized to MBE (0.17%) + xylitol, xylitol, or a control group. Honokiol and magnolol inhibited excitatory amino acid-evoked cation signals and N-methyl-D-aspartate acid (NMDA)–induced seizures.63 Honokiol was more selective in blocking the NMDA receptor and demonstrated greater inhibition against NMDA-induced seizures. A small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms.45, Avoid use during pregnancy and lactation because of limited clinical data. The mechanism involved inhibition of angiogenesis, and histological analysis of the pleural tumors revealed application of the gel increased the rate of apoptosis.35, Honokiol reduced the infarct zone, duration of ventricular tachycardia, and ventricular fibrillation in coronary ligated rats.59 The cardioprotective effect may be associated with increased nitric oxide synthesis.60, Honokiol inhibited hydrogen peroxide–induced apoptosis in human lens epithelial cells by modulating various signaling pathways in cataract formation.61, A mixture of honokiol and magnolol at 20 and 40 mg/kg inhibited stress-induced decreases of serotonin in the frontal cortex, hippocampus, striatum, hypothalamus, and nucleus accumbens in mice. Magnolia bark extract is found in supplements, tea, toothpaste, and topical oils and cream. MBE, honokiol, and magnolol were all effective against killing bacteria responsible for halitosis and formation of dental caries (ie, Streptococcus mutans).11, 12, 13 The MIC ranged from 8 to 31 mcg/mL for magnolol, honokiol, and MBE against Porphyromonas gingivalis, Fusobacterium nucleatum, and S. mutans. One small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms. Magnolia bark is a natural remedy sourced from the magnolia tree (Magnolia officinalis) that has been used for centuries in traditional Chinese medicine (TCM).It contains a compound called honokiol that mimics the function of estrogen in the body. Follow the directions for use. Avoid use during pregnancy and lactation because of limited clinical data. The hope is to not simply mask bad breath, as most strongly flavored mints and gums do, but to kill odor-causing bacteria. Both compounds also enhanced vitamin D3 and all-trans-retinoic acid induced HL-60 leukemic cell differentiation.31, Magnolol suppressed growth of cultured human U373 malignant glioblastoma cells by inhibiting DNA synthesis and activating apoptosis. Another plant extract combination containing M. officinalis, KIOM-79, inhibited xylose-induced lens opacity.43 KIOM-79 also protected human lens epithelial-B3 cells from the toxic effects of high glucose levels by inhibiting transforming growth factor beta, which is involved in the pathophysiology of ocular damage. It is possible that authorities may access the data without any legal remedy. Maybe not. Cutipure CLR … View abstract. But does this mean anybody can take the extract? An animal study found that honokiol and magnolol blocked uterine contractions in rat uterus. These enable personalised online advertisements and extended analysis and evaluation options regarding the target group and user behaviour. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity. Magnolol is able to cross the blood brain barrier, as documented by pharmacokinetic studies in rats.32, Honokiol alone inhibited the growth of human lung cancer A549 in lung carcinoma models, and when combined with cisplatin, enhanced antitumor efficacy by increasing apoptosis and inhibition of angiogenesis.33 Honokiol inhibited several human breast cancer cell lines, as well as drug-resistant breast cancer cell lines. Magnolia Grandiflora Bark Extract. This product may be unsafe when used before surgery or other medical procedures. Back To TOC All patients’ hypersensitivity were validated with positive reactions to patch testing.72, 76, Dietary administration of MBE in rats at doses of up to 480 mg/kg in a 21-day study and 240 mg/kg in a 90-day study resulted in no clinically important toxicity.7 Some sources document the development of progressive interstitial renal fibrosis in patients consuming an herbal blend containing M. officinalis.66, 67 In vitro studies demonstrate no genotoxic effects from MBE in chromosomal aberration assays.68 One study documented that magnolol in liver graft preservation enhanced apoptotic events under cold preservation instead of preserving hepatocyte integrity.69. Chemical Composition.—The various species of Magnolia probably have analogous composition. Honokiol Promotes relaxation and sense of calm, while magnolol has anti-inflammatory and antineoplastic effects. et Wils. Join the myNIVEA community to get access to personalised skin care tips and tricks, membership only offers, new product information and loads more! It has also been used to treat fever, anxiety, nervous disorders, depression, muscular pain, abdominal fullness, constipation, and thrombotic stroke.6, 7, 8, 9 In Chinese and Japanese folk medicine, MBE has been used to treat bronchitis and emphysema.10, Magnolol and honokiol are the 2 primary active phenolic constituents of MBE.1, 2, 3. After 30 days, MBE + xylitol and xylitol gums provided significant protection against plaque acidity (P=0.01 and P=0.04, respectively) compared to baseline, with protection by MBE also being significantly better than control (P=0.04) Additionally, both MBE + xylitol and xylitol gums improved mutans streptococci levels and bleeding upon probing significantly better than control. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Other ingredients in the smoothie can help mask the bark’s taste in case it doesn’t appeal to you. Honokiol (C18H18O2), a biphenolic phytochemical, is one of the bioactive constituents of the bark and leaves of Magnolia plant species. You should talk with your health care provider for complete information about the risks and benefits of using this product. Hence, you can mix it in a glass of plain water or juice. Great. It has been used in traditional Chinese medicine called houpu or hou po for hundreds of years, and it is recognized worldwide for its medicinal properties. Magnolia bark extract has been used for centuries for its anti-inflammatory purposes in Traditional Chinese Medicine. USA). No dermatologic adverse effects were documented with topical application of magnolol and honokiol; however, several cases of allergic dermatitis have been documented in case reports. A human skin irritation test in 30 healthy patients demonstrated no adverse effects from topical application of the phenolic compounds. The supplement reduced evening cortisol levels and may have improved systolic blood pressure as well as perceived stress.46 Another randomized, placebo-controlled trial indicated that the same dietary supplement may reduce mild transitory anxiety in premenopausal women.46, 47 Postmenopausal women with mild affective symptoms, borderline anxious-depressive behaviors, and/or sleep disorders were enrolled in a randomized, controlled trial (n=634) that compared the activity of isoflavones + lactobacilli with and without MBE. Additive adverse reactions with antiplatelet medications may occur in patients also self-medicating with magnolol. MBE and honokiol may interact with benzodiazepines. Both delivery forms were well tolerated with no reported problems.74, 75 A 2017 systematic review of chewing gum and its impact of halitosis parameters (ie, volatile sulfur compounds, organoleptic scores) in adults evaluated 10 trials that exhibited high heterogeneity; no study was at low risk of bias in all analysis items. Mint candies containing MBE 0.2% reduced oral bacteria by 99.9% within 5 minutes of treatment. For specific ingredient action please refer to product information. Studies also indicate magnolia bark can improve insulin resistance, and contribute to reductions in triglycerides and cholesterol. This information is not specific medical advice and does not replace information you receive from your health care provider. PhytoDefense CLR™ by CLR Berlin acts as an anti-inflammatory and anti-redness agent. Dosing recommendations include taking a 300 mg capsule of Relora 2 to 3 times per day. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Medically reviewed by Drugs.com. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. *All information provided on this page is general information only and is not necessarily applicable to products containing these ingredients. Scientific Name(s): Magnolia officinalis Rehd. 2012;23(3):76-9. MAGNOLIA GRANDIFLORA BARK EXTRACT. MBE is commercially available in the United States and throughout Europe. Always read the label. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Documentation on the materials and extracts for several studies is also limited. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. Magnolol prevented hypotension, bradycardia, and multiple organ failure induced by lipopolysaccharide in rats.64 Potential mechanisms of action include: reducing the plasma TNF-alpha and nitrate/nitrite concentrations, suppressing organ superoxide anion level, and suppressing the blood coagulation cascade and expression of inflammatory genes. The mechanism of action appears to involve reducing the levels of eicosanoid mediators rather than affecting glucocorticoid activity or steroid hormone activity from the adrenal gland.15, 16, In mice, honokiol and magnolol reduced inflammatory pain by blocking the inflammatory mediators substance P and prostaglandin E2, and the neurotransmitter glutamate.17 Honokiol inhibited several signal transduction cascades (eg, protein kinase C, mitogen-activated protein kinase, nuclear transcription factor kappa-B) involved with regulating inflammatory mediator and gene expression.18, In vitro and animal studies document potent antioxidant activity for magnolol and honokiol in protecting against myocardial and cerebral ischemia by inhibiting neutrophil infiltration and reactive oxygen species production.48, 49, 50, Magnolol and honokiol have weak activity against HIV-1 in human peripheral blood mononuclear cells.51, Extracts of M. officinalis may have benzodiazepine-like activity as documented by a strong affinity on the benzodiazepine-binding site of the gamma aminobutyric acid (GABA) receptor. The magnolia extract and magnesium combination appeared to be effective in reducing psychoaffective and sleep disturbances from menopause.45 A small pilot study examined the effects on body weight from a dietary supplement containing extracts of M. officinalis and Phellodendron amurense in 28 premenopausal women. There are certain things to be kept in mind. Cancer . It is lipophilic active ingredient, based on an extract of the bark of magnolia grandiflora … The Best Anti-Wrinkle Treatment for Your Skincare Routine. Select one or more newsletters to continue. Common Name(s): "Hu-bak", Magnolia bark. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes MBE. Documentation on the materials and extracts for several studies is also limited. It is a bioactive compound found. MBE is commercially available in the United States and throughout Europe, as documented by Internet search engines. Research shows compounds in magnolia bark extract may help guard against weight gain and decrease body fat. Magnolia Grandiflora Price - Select 2020 high quality Magnolia Grandiflora Price products in best price from certified Chinese Magnolia Bark Extract Powder manufacturers, Magnolia Denudata suppliers, wholesalers and factory on Made-in-China.com US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Caries Res. Magnolia Grandiflora Extract Magnolol, US $ 10 - 13 / Kilogram, Herbal Extract, magnolia grandiflora, Powder.Source from Xian Tonking Biotech Co., Ltd. on Alibaba.com. An animal study documented that honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5. Modern science is now exposing the health benefits of magnolia bark supplements. Magnolia bark also appears to have potent antibacterial and anti-inflammatory effects. With age, our immune system slowly becomes less effective and inflammation can increase. NEW: NIVEA Q10 Power Range for Mature Skin, NIVEA Hyaluron Cellular Filler Elasticity. Studies suggest magnolia bark may deliver broad benefits for weight and metabolic health. Nature Magnolia Bark Extract 98% Magnolol Powder . This information relates to an herbal, vitamin, mineral or other dietary supplement. Magnolia bark extract is a fluid alcohol extracted from the bark of a magnolia plant and frequently administered as an herbal medicine. Honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5 contains about 230 species which originate from Eastern and... C18H18O2 ), a Multifunctional Antiangiogenic and Antitumor Agent: [ ANTIOXIDANTS & REDOX SIGNALING any patient health... Cell proliferation, induced cell cycle arrest, and nucleus accumbens at 40 mg/kg these.. 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